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A PI3-kinase mediated negative feedback regulates neuronal excitability at the Drosophila neuromuscular junction
Use-dependent downregulation of neuronal activity (negative feedback) can act as a homeostatic mechanism to maintain neuronal activity at a particular specified value. Disruption of this negative feedback might lead to neurological pathologies such as epilepsy, but the precise mechanisms by which this feedback can occur remain incompletely understood. ...