Now showing items 1-5 of 5
Multiscale Strategies for Cartilage Repair
This thesis uses a multiscale approach to identify and manipulate physiologic and in vitro developmental milieus towards the functional repair of articular cartilage. The overarching goals of this work are to improve ...
Characterization of the Temporomandibular Joint Disc and Fibrocartilage Engineering using Human Embryonic Stem Cells
Fibrocartilages in the body, including the temporomandibular joint (TMJ) disc and knee meniscus, lack intrinsic healing capacity following trauma or disease. Current treatments only address the symptoms of fibrocartilage ...
Development of a Biomimetic Hydrogel Scaffold as an Artificial Niche to Investigate and Direct Neural Stem Cell Behavior
The mature central nervous system has a very limited capacity for self-renewal and repair following injury. Neural stem cells (NSCs), however, provide a promising new therapeutic option and can be readily expanded in vitro ...
Novel Exogenous Agents for Improving Articular Cartilage Tissue Engineering
This thesis demonstrated the effects of exogenous stimuli on engineered articular cartilage constructs and elucidated mechanisms underlying the responses to these agents. In particular, a series of studies detailed the ...
Regional Characterization of the Knee Meniscus and Tissue Engineering with Dermal Stem Cells
Towards understanding regional meniscus characteristics important for tissue engineering efforts, meniscus cells were characterized biomechanically and an effective method for isolating these cells for tissue engineering ...