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Effect of fluid shear stress on the growth and metabolism of human aortic smooth muscle cells
Upon disruption of the integrity of the endothelial monolayer, smooth muscle cells (SMC) may be directly exposed to blood flow and their behavior may be modulated by the local hemodynamic environment. Furthermore, modeling ...
Nonlinear model of external respiration
A mathematical model of the external respiratory system is presented which integrates component models of airway mechanics and gas exchange at the pulmonary capillaries. The respiratory system is lumped into: (1) a conducting ...
Macromolecular permeability of endothelial cells subjected to biochemical and mechanical stimuli
Endothelial cells line all of the vessels of the circulatory system, providing a non-thrombogenic conduit and form the principal barrier to the transport of substances between the blood and the surrounding tissue. The ...
Molecular mechanisms of platelet thrombosis under arterial shear conditions
Pathologic arterial thrombosis is the leading cause of death in many countries. Current therapies provide only moderate protection from heart attack, stroke, and other clinical manifestations of thrombosis. To develop more ...