Now showing items 1-6 of 6
Bone formation by three-dimensional osteoblast culture in biodegradable poly(alpha-hydroxy ester) scaffolds
The feasibility of culturing osteoblasts on biodegradable poly($\alpha$-hydroxy esters) to form new bone was investigated through a series of five studies. The first study demonstrated that rat calvarial osteoblasts attached, ...
Oxygen transport by hemoglobin-based blood substitutes
A dual track approach has been applied to the study of oxygen transport behavior of erythrocyte/hemoglobin mixtures flowing in microvessels. The method includes experimental and theoretical modeling of the microcirculation. ...
Effect of fluid shear stress on the growth and metabolism of human aortic smooth muscle cells
Upon disruption of the integrity of the endothelial monolayer, smooth muscle cells (SMC) may be directly exposed to blood flow and their behavior may be modulated by the local hemodynamic environment. Furthermore, modeling ...
Fabrication of pliable polymer scaffolds for tissue engineering and particulate effects on osteoblast function
Pliable, biodegradable scaffolds with poly(lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) blends have been fabricated using a solvent-casting and particulate-leaching technique. This study investigated the ...
Effect of hemoglobin polymerization on the oxygen transport in hemoglobin solutions and packed cells
The effect of hemoglobin polymerization on the facilitated transport of oxygen in systems containing polymerized hemoglobins has been studied experimentally. In part I of this work, the oxygen transport efficacy of a ...
Biodegradable polymer scaffold fabrication and the creation of tissue-engineered bone
It is estimated that over one million surgeries to restore lost bone function are performed each year in the U.S. Although existing therapies generally result in adequate restoration of mechanical or aesthetic function, ...