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In vivo and in vitro remodeling of a small intestinal submucosa extracellular matrix cardiac patch in an ovine model and splashing bioreactor
Previous studies have demonstrated that surgical patches comprised of small intestinal submucosa (SIS)-derived extracellular matrix (ECM) have biological remodeling potential in various tissues. In this series of experiments, ...
Orthogonal approaches for studying glycosaminoglycan biopolymer
The evolution of glycosaminoglycans (GAGs) in eukaryotic species has been one of great biological mysteries. This thesis investigates the composition, rate of degradation and solution characteristics of aggrecan proteoglycan ...