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A library approach to single site and combinatorial residue contributions to dimerization of BNIP3-like transmembrane domains
A poly-leucine transmembrane domain library was randomized at positions corresponding to contact surfaces for a right-handed crossing of two helices to determine the significance of small residues, GxxxG motifs, and hydrogen ...
Functional and structural studies of the Influenza A virus polymerase subunit PB1 and its complex with the PA subunit
The influenza virus RNA polymerase is a heterotrimeric complex of PA, PB1, and PB2. PB1 functions in RNA elongation, 5' and 3' viral RNA binding, and has an endonuclease activity. For detailed biochemical and structural ...