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Evolutionary fates within a microbial population highlight an essential role for protein folding during natural selection
The fitness function developed in this thesis directly links the physicochemical properties of an enzyme to evolutionary fates in a quantitative and predictive manner through a comparative study of empirical and simulated ...
Experimental evolution of TetX2: Correlating changes in fitness to their structural and functional origins
The study of protein evolution and adaptation resides at the junction between the disciplines of biological chemistry and evolutionary biology. We chose the B. thetaiotaomicron tetracycline resistant enzyme TetX2, as our ...