Now showing items 1-6 of 6
Developing Novel Protein-based Materials using Ultrabithorax: Production, Characterization, and Functionalization
Compared to 'conventional' materials made from metal, glass, or ceramics, protein-based materials have unique mechanical properties. Furthermore, the morphology, mechanical properties, and functionality of protein-based ...
The Role of Base Modifications on Tyrosyl-tRNA Structure, Stability, and Function in Bacillus subtilis and Bacillus anthracis
tRNA molecules contain more than 80 chemically unique nucleotide base modifications that contribute to the chemical and physical diversity of RNAs as well as add to the overall fitness of the cell. For instance, base ...
Evolutionary fates within a microbial population highlight an essential role for protein folding during natural selection
The fitness function developed in this thesis directly links the physicochemical properties of an enzyme to evolutionary fates in a quantitative and predictive manner through a comparative study of empirical and simulated ...
Structural and Functional Studies on the Infectious Salmon Anemia Virus Nucleoprotein
Genome packaging for viruses with segmented genomes is often a complex problem. This is particularly true for influenza viruses and other orthomyxoviruses which are able to cause infectious disease, and even worldwide ...
Copper as a biological yin-yang element: Structural dynamics, protein -protein interactions and transfer mechanisms of copper transport proteins
Copper (Cu) can be considered as a biological yin-yang element, because it is essential but toxic at the same time. To manage this paradox, cells have evolved complex molecular Cu transport pathways, in which Cu chaperones ...
Exploration of DNA binding selectivity, transcriptional regulation, and evolutionary relationships of the Hox protein Ultrabithorax
Hox transcription factors direct differentiation in all tissue layers and many organ systems and therefore have highly specific tissue-dependent functions. The DNA-binding homeodomain of Hox proteins can bind a wide array ...