Now showing items 1-6 of 6
Development and Evaluation of Approaches for Quantitative Optical Molecular Imaging of Neoplasia
This thesis develops and evaluates three approaches for quantitative molecularly-targeted optical imaging of neoplasia. The first approach focuses on widefield imaging of biomarkers near the tissue surface for early detection ...
Modulation of Chondrogenic and Osteogenic Differentiation of Mesenchymal Stem Cells through Signals in the Extracellular Microenvironment
Damage to synovial joints results in osteochondral defects that only heal with inferior fibrous repair tissue. Since mesenchymal stem cells (MSCs) play a vital role in the natural development, maintenance, and repair of ...
Computational and Theoretical Analysis of Influenza Virus Evolution and Immune System Dynamics
Influenza causes annual global epidemics and severe morbidity and mortality. The influenza virus evolves to escape from immune system antibodies that bind to it. The immune system produces influenza virus specific antibodies ...
Development of a Thermoresponsive and Chemically Crosslinkable Hydrogel System for Craniofacial Bone Tissue Engineering
A novel injectable hydrogel system for cell delivery in craniofacial bone tissue engineering was developed in this work. The hydrogel employs a dual solidification mechanism by containing units that gel upon temperature ...
Surface-immobilized adeno-associated virus nanoparticles for applications in controlled gene delivery and biosensing
Adeno-associated virus (AAV) is a 25 nm replication deficient DNA virus most commonly studied for human gene therapy applications. The work detailed in this thesis investigates the controlled delivery of AAV from surfaces ...
Novel Methods for Reducing Breast Dose During Computed Tomography Scans
Pediatric female and young adult female patients who undergo computed tomography (CT) scanning may be at higher risk for developing radiation-induced breast cancer later in life. Thus, the purpose of this thesis was to ...