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Metabolism of 5 alpha-cholest-8(14)-en-3 beta-ol-15-one in 15-ketosterol-adapted cells
5$\alpha$-Cholest-8(14)-en-3$\beta$-ol-15-one is a potent inhibitor of cholesterol biosynthesis in cultured cells. Cells derived from the CHO K-1 cell line have been isolated based on their ability to grow in high ...
The induced evolution of Arabidopsis thaliana cycloartenol synthase and the cloning of Oryza sativa cycloartenol synthase
In the biosynthesis of cholesterol in mammals and ergosterol in fungi, oxidosqualene is cyclized to lanosterol by lanosterol synthase. Similarly, the biosynthesis of plant sterols includes the conversion of the same ...
Construction and characterization of purine repressor mutants with altered oligomerization states
X-Ray crystallographic structure and deletion mutagenesis of LacI have demonstrated that three-leucine-heptad repeats (LHR3), located at the C-terminus, are critical for dimer-dimer interaction to form tetramer. We are ...