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Poly(ethylenimine) as a gene delivery vehicle, and its potential for gene therapy
Poly(ethylenimine) (PEI) is a polycation with proven success as a gene delivery vehicle both in vitro and in vivo. The work described herein addresses several aspects of PEI-mediated gene delivery. First, a model system ...
Virtual bioinstrumentation: Integrating biomedical experimentation with systems-level modeling and analysis
This dissertation is a treatise on the merging of biomedical experimentation with modern data acquisition and analysis as an integrated teaching and research platform. Virtual (i.e. computer-based) instrumentation forms ...
Effects of shear stress and cyclic strain on the expression of thrombin receptor gene in human vascular endothelial and smooth muscle cells
Mechanical forces such as shear stress and cyclic strain have been shown to regulate expression of many genes that can alter vascular functions such as cell proliferation, leading to the development of vascular diseases ...