Now showing items 1-5 of 5
Syntheses, bioactivities and conformations of peptidomimetics containing 2,3-methanoamino acids
Asymmetric syntheses of E- and Z-2,3-methanomethionine (ie E- and Z-cyclo-Met), protected Z-2,3-methanoarginine, and Z-2,3-methanoaspartic acid derivatives have been developed. These functionalized 2,3-methanoamino acids ...
Transition metal-catalyzed hydroboration
Model studies on rhodium catalyzed hydroborations of sterically unbiased alkenes with catecholborane provided evidence for the role of d$\pi$-p$\pi$ bonding in these transformations. Catalyzed hydroborations of ...
Stereoselective methodology for syntheses of biologically active compounds
The lipase from Pseudomonas sp. K-10 catalyzes enantioselective hydrolyses of methyl sulfinylacetates. These are used in the asymmetric SPAC (Sulfoxide Piperidine And Carbonyl) transformation, a multistep reaction of a ...
Rhodium(I) catalyzed hydroboration
The stereochemical outcomes and trends of catalysis of hydroboration of alkenes by catecholborane using rhodium(I) catalysts is examined. For 1,2-chirality transfer in simple allylic alcohol derivatives with aliphatic ...
Application of enzyme-mediated esterifications to the resolution of chiral alcohols and phosphines
Optically active allylic, propargylic, and aliphatic alcohols (33 examples) were obtained by kinetic resolution using transesterification catalyzed by an enzyme from Pseudomonas sp. (Amano Enzyme Co., AK). In every case ...