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Ras-dependent and Ras-independent effects of PI3K in Drosophila motor neurons
The lipid kinase PI3K plays key roles in cellular responses to activation of receptor tyrosine kinases or G protein coupled receptors such as the metabotropic glutamate receptor (mGluR). Activation of the PI3K catalytic ...
A PI3-kinase mediated negative feedback regulates neuronal excitability at the Drosophila neuromuscular junction
Use-dependent downregulation of neuronal activity (negative feedback) can act as a homeostatic mechanism to maintain neuronal activity at a particular specified value. Disruption of this negative feedback might lead to ...