Now showing items 1-3 of 3
Ras-dependent and Ras-independent effects of PI3K in Drosophila motor neurons
The lipid kinase PI3K plays key roles in cellular responses to activation of receptor tyrosine kinases or G protein coupled receptors such as the metabotropic glutamate receptor (mGluR). Activation of the PI3K catalytic ...
Negative Feedback Mechanisms Regulating Neurotransmitter Release at the Drosophila Neuromuscular Junction
Homeostasis is an indispensable phenomenon in the maintenance of living organisms. Genetic defects which disrupt negative feedback processes can impact homeostatic regulation, potentially resulting in disease. To uncover ...
A PI3-kinase mediated negative feedback regulates neuronal excitability at the Drosophila neuromuscular junction
Use-dependent downregulation of neuronal activity (negative feedback) can act as a homeostatic mechanism to maintain neuronal activity at a particular specified value. Disruption of this negative feedback might lead to ...