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Collagenous tissue engineered constructs to investigate the role of decorin on collagen fibrillogenesis and tissue mechanics
Decorin, a small leucine rich proteoglycan, has been reported to control collagen fibrillogenesis, thereby influencing the tensile properties of collagenous tissues. In this research work, decorin deficient cells (Dcn -/- ...
Orthogonal approaches for studying glycosaminoglycan biopolymer
The evolution of glycosaminoglycans (GAGs) in eukaryotic species has been one of great biological mysteries. This thesis investigates the composition, rate of degradation and solution characteristics of aggrecan proteoglycan ...