Now showing items 1-6 of 6
Development of a High-Throughput 3D Tumor Model for Bone Sarcomas
Preclinical drug testing commonly relies on the use of two-dimensional (2D) cultures, which allow for rapid drug screening in vitro. However, 2D cultures are unable to capture the complexity of the native three-dimensional ...
Biodegradable Hydrogel Composites for Growth Factor and Stem Cell Delivery in Osteochondral Tissue Engineering
Cartilage has a limited endogenous ability for self-repair and current clinical treatments for damaged or diseased cartilage tissue are insufficient. Additionally, there is a biological and mechanical interplay between ...
Engineering Three Dimensional In Vitro Models of Bone Tumors for Drug Testing and Mechanistic Studies
Development of anti-cancer therapeutics has been traditionally reliant on two-dimensional (2D) systems and animal models, both of which have major limitations that contribute to the poor clinical translation of preclinical ...
Adeno-Associated Virus-Based Gene Delivery Approaches for Tissue Engineering
Tissue engineering constitutes non-trivial processes that can be promoted through combinations of cells, materials and bioactive factors. The formation of tissues and organs demands spatiotemporal precision that cannot, ...
Leveraging Biomaterials for the Treatment of Large Infected Tissue Defects
While the body has an incredible ability to heal, host and external factors may overwhelm its innate regenerative capacity. In these instances, a tissue defect may occur. Tissue defects (regions of either necrotic tissue ...
Tissue-Engineered Tumor Microenvironments for Bone Sarcoma
Preclinical methods interrogation of cancer biology and of evaluation of potential therapeutics rely heavily on the use of monolayer, adherent culture on tissue culture treated polystyrene dishes. However, these techniques ...