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From Gene Trees to Species Trees: Algorithms for Parsimonious Reconciliation
One of the criteria for inferring a species tree from a collection of gene trees, when gene tree incongruence is assumed to be due to incomplete lineage sorting (ILS), is minimize deep coalescence , or MDC. Exact algorithms ...
Improved Understanding of Apoptosis and Metabolism in Chinese Hamster Ovary Cell Culture
Mammalian cell culture has gained importance in biotechnology for the development of therapeutic and diagnostic agents. Among them, Chinese hamster ovary (CHO) cells are regarded as the mammalian cell "workhorse". The use ...
A Sequence-Based, Population Genetic Model of Regulatory Pathway Evolution
Complex phenotypes with genetic cause are understood through many processes, including regulatory pathways, but our evolutionary understanding of these critical structures is undermined by poor models which fail to preserve ...
Change in cell motility and metabolism following culture under low shear conditions
Recent studies suggest that the human immune system, and in particular lymphocyte function, may be suppressed during space flight. However, the mechanisms by which mechanical forces affect the function of immune cells are ...
A new implementation of Super Resolution technique in PET imaging
A new implementation for Super-Resolution (SR) techniques has been proposed. This new SR implementation has multiple clinical advantages versus the original standard implementation. We tested and validated this new approach ...