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Impact loading and functional tissue engineering of articular cartilage
This thesis presents two advances for alleviating the problem of articular cartilage degeneration: mitigating degradative changes that follow mechanically induced injuries and growing functional neo-cartilage for diseased ...
Three-dimensional architecture of the outer hair cell lateral wall as determined by electron tomography
Cochlear outer hair cells (OHCs) are understood to provide the basis for mechanical amplification in the cochlea through electromotility, a phenomenon in which OHCs change length in response to variations in transmembrane ...
Promotion and control of angiogenic activity in poly(ethylene glycol) diacrylate hydrogels for tissue engineering applications
Promotion and control of angiogenic activity have been achieved by covalently linking an angiogenic-signaling protein or peptide to poly(ethylene glycol) diacrylate hydrogels, thereby yielding a system which can be used ...
Orthogonal approaches for studying glycosaminoglycan biopolymer
The evolution of glycosaminoglycans (GAGs) in eukaryotic species has been one of great biological mysteries. This thesis investigates the composition, rate of degradation and solution characteristics of aggrecan proteoglycan ...