Now showing items 1-10 of 256
THE LUNAR EXOSPHERE
Synthetic studies towards the total synthesis of discorhabdin C
Two synthetic approaches towards the total synthesis of discorhabdin C (3) are described. The general strategy for construction of azacarbocyclic spiro dienone system is to employ an intramolecular para-phenolic alkylation ...
Physiologically relevant reactions of myoglobin and hemoglobin with nitric oxide
Recent clinical trials involving administration of a cell-free hemoglobin based blood substitute have shown that several detrimental side effects are the result of reactions with nitric oxide produced by endothelial cells. ...
Studies on the lipid metabolism of cestodes
The problem of the energy relationship is fundamental in any investigation of animal physiology. Endoparasitic helminths present a rather unique ecological situation since the energy sources and substrates for the parasite ...
Molecular biological approaches to biomedical problems in sterol and terpene biosynthesis
Molecular biological techniques represent powerful tools with applications to a wide variety of biomedical problems. Described herein is the use of metabolic engineering to manipulate sterol biosynthesis for medicinal ...
Insights into peroxisome matrix protein import and IBA metabolism through analysis of IBA-response mutants
Peroxisomes are single membrane-bound organelles that function to compartmentalize certain metabolic reactions critical to plant and animal development. I have studied peroxisomal processes in the model plant Arabidopsis ...
Escort protein regulation of the human mitochondrial molecular chaperone mtHsp70
Mitochondrial Hsp70 molecular chaperones (mtHsp70) are nuclear-encoded proteins that are needed for the import of proteins into the mitochondrial matrix, biogenesis of Fe/S-clusters involved in energy metabolism, and stress ...
Role oflac repressor hinge region and operator DNA sequence in complex formation
A study of the lac repressor hinge region was undertaken to decipher its role in the function of DNA binding and communication between binding sites within the protein. Specific mutations were designed, and the proteins ...