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Computational and Theoretical Analysis of Influenza Virus Evolution and Immune System Dynamics
Influenza causes annual global epidemics and severe morbidity and mortality. The influenza virus evolves to escape from immune system antibodies that bind to it. The immune system produces influenza virus specific antibodies ...
The biophysics of intracellular transport driven by structurally-defined systems of motor proteins
The number of motor proteins attached to cellular cargos is widely believed to influence intracellular transport processes and may play a role in transport regulation. However, to date, investigating the biophysics of ...
Photothermal therapies using near infrared absorbing nanoparticles
This thesis describes the development of new infrared (NIR) absorbing nanoparticles for use in biomedical therapeutic applications. Gold nanoshells with a dielectric core of silica developed at Rice University have shown ...
Three-dimensional architecture of the outer hair cell lateral wall as determined by electron tomography
Cochlear outer hair cells (OHCs) are understood to provide the basis for mechanical amplification in the cochlea through electromotility, a phenomenon in which OHCs change length in response to variations in transmembrane ...