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In vivo and in vitro remodeling of a small intestinal submucosa extracellular matrix cardiac patch in an ovine model and splashing bioreactor
Previous studies have demonstrated that surgical patches comprised of small intestinal submucosa (SIS)-derived extracellular matrix (ECM) have biological remodeling potential in various tissues. In this series of experiments, ...
Collagenous tissue engineered constructs to investigate the role of decorin on collagen fibrillogenesis and tissue mechanics
Decorin, a small leucine rich proteoglycan, has been reported to control collagen fibrillogenesis, thereby influencing the tensile properties of collagenous tissues. In this research work, decorin deficient cells (Dcn -/- ...
Targeting A549 and MCF7 with small bivalent molecules coated on liposomes
Bilamellar invaginated vesicles (BIVs) are liposomal/nanopartical delivery vehicles that have the ability to penetrate tight barriers throughout the target organ including the interstitial pressure gradient in large solid ...
Orthogonal approaches for studying glycosaminoglycan biopolymer
The evolution of glycosaminoglycans (GAGs) in eukaryotic species has been one of great biological mysteries. This thesis investigates the composition, rate of degradation and solution characteristics of aggrecan proteoglycan ...