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The mystery of SPO1 delayed early genes
Genes of the Bacillus subtilis infecting bacteriophage SPO1 are classified as early, middle or late genes, based on which sigma factor is used for their transcription. Within the early gene category, there are two subsets ...
Anticipation of Nitric Oxide Stress in the Human Commensal Fungus Candida albicans
Candida albicans is the most common human commensal fungus, able to colonize host niches such as skin, mouth and gastrointestinal tract. Colonization of diverse microenvironments requires the ability to evade or overcome ...
The Role of Base Modifications on Tyrosyl-tRNA Structure, Stability, and Function in Bacillus subtilis and Bacillus anthracis
tRNA molecules contain more than 80 chemically unique nucleotide base modifications that contribute to the chemical and physical diversity of RNAs as well as add to the overall fitness of the cell. For instance, base ...
Structure of the hepatitis E virus-like particle suggests me chanisms for virus assembly and receptor binding
This thesis reports the atomic structure of the Hepatitis E virus (HEV) in the form of a virus-like particle (VLP). HEV is a small, non-enveloped RNA virus in the family Hepeviridae and is the principal cause of endemic ...
Monitoring iron-sulfur cluster content of human glutaredoxin 2 using fluorescence proteins
Current methods for directly determining whether an iron-sulfur cluster has been synthesized on a protein in vivo typically require that the protein of interest is purified prior to analysis for bound metallocluster. To ...