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An Investigation of the Biophysical and Biochemical Properties of Perlecan/HSPG2: Implications for Bone Mechanotransduction and Endochondral Ossification
Perlecan, also known as heparan sulfate proteoglycan 2 (HSPG2), is a very large secreted proteoglycan ubiquitously expressed in all basement membranes and in the territorial matrix of skeletal tissues. Perlecan is ...
Regulation of Innate Immune Cells
Immune cells such as neutrophils and monocytes enter tissues after tissue damage and clear cell debris to allow repair cells such as fibroblasts to close the wound. Monocytes also differentiate into fibroblast-like cells ...
Ras-dependent and Ras-independent effects of PI3K in Drosophila motor neurons
The lipid kinase PI3K plays key roles in cellular responses to activation of receptor tyrosine kinases or G protein coupled receptors such as the metabotropic glutamate receptor (mGluR). Activation of the PI3K catalytic ...
Negative Feedback Mechanisms Regulating Neurotransmitter Release at the Drosophila Neuromuscular Junction
Homeostasis is an indispensable phenomenon in the maintenance of living organisms. Genetic defects which disrupt negative feedback processes can impact homeostatic regulation, potentially resulting in disease. To uncover ...
A PI3-kinase mediated negative feedback regulates neuronal excitability at the Drosophila neuromuscular junction
Use-dependent downregulation of neuronal activity (negative feedback) can act as a homeostatic mechanism to maintain neuronal activity at a particular specified value. Disruption of this negative feedback might lead to ...