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MUC16/CA125 Regulation by the Proinflammatory Cytokines TNF α and IFNγ and the PPARγ Agonist Rosiglitazone in Breast and Ovarian Cancers
MUC16 is a high molecular weight transmembrane mucin (TM) carrying the CA125 epitope, a well-known molecular marker for human cancers. TMs are restricted to the apical surface of normal epithelia. TMs not only are ...
Toward a better understanding of human polarized epithelial biology: Mucin 4 in endometrium and polarity complexes in salivary epithelium
The epithelium is one of four major tissues in the human body. It covers every surface and cavity. Epithelial cells have an intracellular organization they use to differentiate the top, or apical surface, of the cell ...
A two-pronged approach towards the development of novel therapeutics for advanced endometrial cancer
Endometrial cancer is the fourth most common cancer among women. The standard of care involves hysterectomy with adjuvant radiation and chemotherapy for advanced disease. Despite these efforts, treatment of advanced and ...