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The study of an autocrine signal transduction pathway that represses cell proliferation in Dictyostelium discoideum
Many secreted factors are believed to inhibit cell proliferation in certain tissues such as tumors; however, the identity and action of most of these factors remains unknown. The recent identification of two autocrine ...
Functional and structural studies of the Influenza A virus polymerase subunit PB1 and its complex with the PA subunit
The influenza virus RNA polymerase is a heterotrimeric complex of PA, PB1, and PB2. PB1 functions in RNA elongation, 5' and 3' viral RNA binding, and has an endonuclease activity. For detailed biochemical and structural ...