Now showing items 1-6 of 6
Development of bioactive polyurethaneureas to support endothelialization
Vascular diseases are responsible for the majority of deaths in the United States. Synthetic materials have been developed for blood vessel substitutes but not suitable for small diameter vascular applications such as ...
Electrophysiological investigation of prestin function: Impact of cysteine replacement and characterization of self-association during voltage stimulation
Almost 25 years ago unique piezoelectric activity was discovered in neuroepithelial cells of the mammalian cochlea. These cells, outer hair cells (OHCs), are mechanoelectrical transducers capable of converting changes in ...
Optimization of cryogen spray cooling: Increasing epidermal protection during cutaneous laser procedures
Cryogen spray cooling (CSC) is an effective method to minimize epidermal damage during laser treatment of various cutaneous anomalies such as port wine stains (PWS). We examined the mechanism of heat removal by CSC from ...
Poly(ethylenimine) as a gene delivery vehicle, and its potential for gene therapy
Poly(ethylenimine) (PEI) is a polycation with proven success as a gene delivery vehicle both in vitro and in vivo. The work described herein addresses several aspects of PEI-mediated gene delivery. First, a model system ...
Virtual bioinstrumentation: Integrating biomedical experimentation with systems-level modeling and analysis
This dissertation is a treatise on the merging of biomedical experimentation with modern data acquisition and analysis as an integrated teaching and research platform. Virtual (i.e. computer-based) instrumentation forms ...
Effects of shear stress and cyclic strain on the expression of thrombin receptor gene in human vascular endothelial and smooth muscle cells
Mechanical forces such as shear stress and cyclic strain have been shown to regulate expression of many genes that can alter vascular functions such as cell proliferation, leading to the development of vascular diseases ...