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Automated tracking of tumor invasion in three dimensional extracellular matrix analogs and a novel stochastic analysis of the cell trajectories
Tumor cell migration and invasion of body tissues are prerequisite mediators for lymphatic or hematogenous cancer dissemination. To date, there is insufficient understanding of what triggers the metastatic cascade, and of ...
Development of an injectable, in situ crosslinkable, degradable polymeric carrier for osteogenic cell populations
An injectable, in situ crosslinkable, degradable polymeric carrier for osteogenic cell populations was developed. Specifically, a system for encapsulating marrow stromal osteoblasts in gelatin microspheres has been implemented ...
Hybrid computational modeling of cell population and mass transfer dynamics in tissue growth processes
This work presents a comprehensive hybrid computer model simulating the cell population and mass transfer dynamics during tissue growth processes. The model has three major components: (a) a discrete algorithm simulating ...
Modeling viscoelastic free surface and interfacial flows, with applications to the deformation of droplets and blood cells
This thesis models viscoelastic free surface and interfacial flows. Capillarity and viscoelasticity are important in many interesting problems, e.g. the deformation of droplets and blood cells, coating flows of polymer ...
The effects of mechanical forces on lymphocyte adhesion and migration
The immune system, and in particular, lymphocyte function is depressed under microgravity conditions. Cells may sense altered gravitational forces through changes in the mechanical forces they experience. To study the ...