Now showing items 1-5 of 5
A PI3-kinase mediated negative feedback regulates neuronal excitability at the Drosophila neuromuscular junction
Use-dependent downregulation of neuronal activity (negative feedback) can act as a homeostatic mechanism to maintain neuronal activity at a particular specified value. Disruption of this negative feedback might lead to ...
Structure of the hepatitis E virus-like particle suggests me chanisms for virus assembly and receptor binding
This thesis reports the atomic structure of the Hepatitis E virus (HEV) in the form of a virus-like particle (VLP). HEV is a small, non-enveloped RNA virus in the family Hepeviridae and is the principal cause of endemic ...
Triterpene biosynthesis in plants: Oxidosqualene cyclization in Arabidopsis thaliana
The enzymatic conversion of oxidosqualene to cyclic triterpenes represents the key step in the biosynthesis of more than 20,000 triterpenoids. These compounds are widely distributed in nature among plants, animals, fungi, ...
Copper as a biological yin-yang element: Structural dynamics, protein -protein interactions and transfer mechanisms of copper transport proteins
Copper (Cu) can be considered as a biological yin-yang element, because it is essential but toxic at the same time. To manage this paradox, cells have evolved complex molecular Cu transport pathways, in which Cu chaperones ...
Investigation of the role of Wee2 in the zebrafish midblastula transition
Zebrafish embryonic development begins with a series of rapid and synchronous cell divisions that quickly partition the zygote into a set of small blastomeres. The minimal cell division cycle during this period consists ...