Now showing items 1-4 of 4
Genetic analysis of microRNA function in Arabidopsis thaliana development
MicroRNAs (miRNAs) are 21-24-nucleotide RNAs that negatively regulate gene expression. Plant miRNAs play important roles in gene regulation by directing cleavage of target mRNAs. The high degree of complementarity between ...
Functional and structural studies of the Influenza A virus polymerase subunit PB1 and its complex with the PA subunit
The influenza virus RNA polymerase is a heterotrimeric complex of PA, PB1, and PB2. PB1 functions in RNA elongation, 5' and 3' viral RNA binding, and has an endonuclease activity. For detailed biochemical and structural ...
The study of an autocrine signal transduction pathway that represses cell proliferation in Dictyostelium discoideum
Many secreted factors are believed to inhibit cell proliferation in certain tissues such as tumors; however, the identity and action of most of these factors remains unknown. The recent identification of two autocrine ...
Exploration of DNA binding selectivity, transcriptional regulation, and evolutionary relationships of the Hox protein Ultrabithorax
Hox transcription factors direct differentiation in all tissue layers and many organ systems and therefore have highly specific tissue-dependent functions. The DNA-binding homeodomain of Hox proteins can bind a wide array ...