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A cell number-counting factor regulates group size in Dictyostelium discoideum
Little is known about how a morphogenetic rearrangement of a tissue is effected by the individual cells. Starving Dictyostelium discoideum cells aggregate to form dendritic streams which then break up into groups of ∼2 x 104 cells. Cell number is sensed using counting factor (CF), a secreted complex of polypeptides. A high extracellular concentration ...