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Remodeling of the extracellular matrix components of the mitral valve due to alterations in the mechanical and chemical environments of the tissue
This body of research explored mitral valve remodeling due to changes in the mechanical and chemical environments of the tissue in order to better predict patient response to medical device and drug therapies. This work ...
Orthogonal approaches for studying glycosaminoglycan biopolymer
The evolution of glycosaminoglycans (GAGs) in eukaryotic species has been one of great biological mysteries. This thesis investigates the composition, rate of degradation and solution characteristics of aggrecan proteoglycan ...