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Ras-dependent and Ras-independent effects of PI3K in Drosophila motor neurons
The lipid kinase PI3K plays key roles in cellular responses to activation of receptor tyrosine kinases or G protein coupled receptors such as the metabotropic glutamate receptor (mGluR). Activation of the PI3K catalytic ...
Negative Feedback Mechanisms Regulating Neurotransmitter Release at the Drosophila Neuromuscular Junction
Homeostasis is an indispensable phenomenon in the maintenance of living organisms. Genetic defects which disrupt negative feedback processes can impact homeostatic regulation, potentially resulting in disease. To uncover ...