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Evolutionary Dynamics Leading to Tigecycline Resistance in Enterococcus faecalis
The rising frequency of multidrug resistant pathogens poses an increasing threat to public health. There is a dire need for novel approaches to combat these deadly pathogens and maintain the efficacy of currently available ...
Cellular fitness as a proxy to determine the physicochemical parameters of an antibiotic efflux pump
Determining the quantitative link between protein function and cellular fitness can be challenging as even the modestly sized genome of Escherichia coli is comprised of thousands of genes. Using an appropriate survey of ...