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Biodegradable Hydrogel Composites for Growth Factor and Stem Cell Delivery in Osteochondral Tissue Engineering
Cartilage has a limited endogenous ability for self-repair and current clinical treatments for damaged or diseased cartilage tissue are insufficient. Additionally, there is a biological and mechanical interplay between ...
Development of a High-Throughput 3D Tumor Model for Bone Sarcomas
Preclinical drug testing commonly relies on the use of two-dimensional (2D) cultures, which allow for rapid drug screening in vitro. However, 2D cultures are unable to capture the complexity of the native three-dimensional ...
Tailored Release of Bioactive Factors from Composite Multidomain Peptide Hydrogels
Multidomain peptides (MDP) self-assemble to form nanofibrous scaffolds well suited to tissue engineering and regeneration strategies. MDPs can present bioactive cues that promote vital biological responses. Orthogonal ...
Leveraging Biomaterials for the Treatment of Large Infected Tissue Defects
While the body has an incredible ability to heal, host and external factors may overwhelm its innate regenerative capacity. In these instances, a tissue defect may occur. Tissue defects (regions of either necrotic tissue ...
Engineering Three Dimensional In Vitro Models of Bone Tumors for Drug Testing and Mechanistic Studies
Development of anti-cancer therapeutics has been traditionally reliant on two-dimensional (2D) systems and animal models, both of which have major limitations that contribute to the poor clinical translation of preclinical ...