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Fibronectin and von Willebrand factor mediated sickle erythrocyte adhesion to human endothelial cells under venous flow conditions
(1988)
Sickle erythrocytes have previously been demonstrated to be abnormally adhesive to human endothelial cells in both static incubation assays and under venous flow conditions. The extent to which human fibronectin and human ...
Effect of shear stress on leukocyte adhesion to vascular endothelium
(1988)
The effect of flow on the adhesion of neutrophils (PMNL) to vascular endothelium was investigated using a parallel plate flow chamber. Human umbilical vein endothelial cells (HUVEC) were cultured on a glass slide which was ...
2D timelapse and 3D fluorescence microscopy with applications to vascular tissue engineering
(1998)
Part of the definition given to the new emerging science discipline of tissue engineering is the understanding of the structure-function relationships at the cellular level. In this context it is important for vascular ...
Effect of shear stress on surface membrane potassium ion permeability of calf pulmonary artery endothelial cells (Potassium ion)
(1989)
This study aims to determine the effect of shear stress on membrane potassium (K$\sp+$) permeability in vascular endothelial cells. Cultured monolayers of calf pulmonary artery endothelial cells, preloaded with $\rm ...
Effect of novel antithrombotic agents on platelet aggregation under flow conditions
(1992)
Epi-fluorescence video microscopy and digital image processing were used to evaluate the effects of three novel anti-platelet agents namely GT-12/I.2HBr (GT-12/I), A4.2HBr and IC, a series of compounds containing the ...
Effects of mechanical loading on osteoblast function using a three dimensional celijpolymer model
(1998)
Mechanisms which trigger bone modeling/remodeling in response to changes in the mechanical environment are still unclear. In a three part study, effects of loading on osteoblast function were investigated using a three ...
Examination of a system for the mechanistic study of tumor cell-platelet interactions under well-defined flow conditions
(2000)
The compelling evidence that platelets play a contributory role in hematogenous metastasis raises a need to elucidate the molecular mechanisms by which tumor cells activate and adhere to platelets. To model the in vivo ...
Adhesion of murine RAW117 lymphoma cells to hepatic sinusoidal endothelial cells: Study of surface molecule interactions under flow and effect of cyclooxygenase and lipoxygenase inhibitors
(2000)
Adhesion of malignant tumor cells under flow conditions to the endothelial monolayer lining the interior of the blood vessels is an important step in the metastatic cascade. This project examined the adhesive interactions ...
von Willebrand factor interaction with subendothelial collagens and platelet surface receptor GPIBalpha under shear conditions
(2002)
The molecular mechanisms of binding interaction among von Willebrand factor, subendothelium and platelets under physiological shear conditions are important medically in hemostasis and thrombosis. By binding both subendothelial ...
Effects of sickle erythrocytes on metabolism and gene regulation in cultured human endothelial cells under flow conditions
(1999)
Sickle cell anemia is characterized by chronic hemolysis and episodic vasoocclusive crises. There are many factors contributing to vascular occlusion in sickle cell patients, with the enhanced, abnormal adhesion of sickle ...