The inducer binding site of the E. coli lactose repressor has been examined by in vitro characterization of mutant proteins with amino acid substitutions at the hypothetical inducer binding site (Sams, C. F., Vyas, N. K., ...

Why do females across a wide range of taxa mate with more than one male? Here, I present the hypothesis that females engage in polyandry as a hedge against genetic incompatibility. I review evidence from the literature ...

The artificial transmutation of the gene is an old problem. Investigators tried to produce mutations artificially, but failed until 1927 when Muller announced that gene mutations could be produced by means of X-rays. This ...

The Drosophila maternal effect mutant, bicaudal (bic), affects the anterior-posterior axis of the embryo. It is incompletely penetrant, producing a variety of lethal embryonic phenotypes, the most severe of which is ...

In order for cells to grow and survive, they must be able to overcome changes in their external environment. For example, stresses such as high or low temperatures and nutrient deprivation have been shown to elicit a ...

We were interested in identifying genes in the dipteran flies Calliphora erythrocephala and Drosophila melanogaster with a role in oogenesis and early embryogenesis. A biochemical screen was used to complement the extensive ...