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Influence of Peroxisomal Import and Receptor Recycling of Peroxisomal Function
Peroxisomes compartmentalize a variety of important metabolic reactions including fatty acid β-oxidation and the related process of IBA β-oxidation. Peroxisomal proteins are encoded by nuclear genes and must be ...
Ras-dependent and Ras-independent effects of PI3K in Drosophila motor neurons
The lipid kinase PI3K plays key roles in cellular responses to activation of receptor tyrosine kinases or G protein coupled receptors such as the metabotropic glutamate receptor (mGluR). Activation of the PI3K catalytic ...
Negative Feedback Mechanisms Regulating Neurotransmitter Release at the Drosophila Neuromuscular Junction
Homeostasis is an indispensable phenomenon in the maintenance of living organisms. Genetic defects which disrupt negative feedback processes can impact homeostatic regulation, potentially resulting in disease. To uncover ...
Genetic analysis of microRNA function in Arabidopsis thaliana development
MicroRNAs (miRNAs) are 21-24-nucleotide RNAs that negatively regulate gene expression. Plant miRNAs play important roles in gene regulation by directing cleavage of target mRNAs. The high degree of complementarity between ...
A PI3-kinase mediated negative feedback regulates neuronal excitability at the Drosophila neuromuscular junction
Use-dependent downregulation of neuronal activity (negative feedback) can act as a homeostatic mechanism to maintain neuronal activity at a particular specified value. Disruption of this negative feedback might lead to ...
Investigation of the role of Wee2 in the zebrafish midblastula transition
Zebrafish embryonic development begins with a series of rapid and synchronous cell divisions that quickly partition the zygote into a set of small blastomeres. The minimal cell division cycle during this period consists ...