Now showing items 21-40 of 13404

    • Investigation of the amyloid-beta aggregation and oxidation using photoluminescent metal complexes 

      Jiang, Bo (2021-12-03)
      Amyloid-β (Aβ), a short peptide of 39 to 42 amino acids, is formed by the cleavage of the amyloid precursor protein by proteases in the membrane of neurons, and self-assembles into aggregated species. These aggregates take oligomeric (soluble) and fibrillar (insoluble) forms, which have been proven to be toxic to our brain, playing a key role of the ...
    • GenomeDepot: Computational Methods for Decoding Biological Information Encoded in Engineered DNA and Microbial Genomes 

      Wang, Qi X (2021-12-03)
      Although great successes have been made in DNA sequencing and genome engineering, fully elucidating the underlying biological information encoded in genomic data, and the ability to fully control biological systems, are still limited. My research has focused on deciphering signatures hidden in genomic data, specifically in engineered synthetic ...
    • Carbon Nanozymes and their Derivatives for Treatment of Oxidative Stress-Related Diseases and Dysfunctions 

      McHugh, Emily (2021-12-03)
      Carbon nanozymes exhibit unique enzyme-like properties and reactivity because of their distinct structural features making them interesting for various fields of application including medicine, catalysis, materials, and batteries. Herein, the process-structure-property-performance space of poly(ethylene glycol)-functionalized hydrophilic carbon cluster ...
    • Mechanical phase transitions in biopolymer networks 

      Arzash, Sadjad (2021-12-03)
      Biopolymer networks are vital components of all living organisms. Cytoskeleton, as a complex intercellular network composed of fibrous proteins such as filamentous actin (F-actin), microtubules and intermediate filaments, provides mechanical stability for the cell. Extracellular matrix (ECM), on the other hand, is an interwoven structure of proteins ...
    • Space--Time Computation of a Ringsail Parachute With Model Thickness 

      Barrios, Dino (2021-12-03)
      The Team for Advanced Flow Simulation and Modeling specializes in computational analysis of geometrically complex parachutes. In earlier computations, the parachutes modeled by our team did not include the fabric thickness in the fluid domain, as doing so would require a large number of elements, which is computationally costly. However, by resolving ...
    • Foam Transport in Porous Media: in-Situ Capillary Pressure Measurement and Application to Enhanced Heavy Oil Recovery 

      Vavra, Eric Daniel (2021-12-03)
      Aqueous foam flow in porous media has been the subject of an increasing number of studies in recent years. Foam is a dynamic colloid that can exhibit unintuitive properties when flowing in porous media; thus, foam experiments often produce unclear or conflicting results. With potentially lucrative applications ranging from enhanced oil recovery (EOR) ...
    • Rater Sensitivity and Bias in Adverse Impact Decision-Making: A Signal Detection Theory Approach 

      Alexander, Leo (2021-12-03)
      The concept of adverse impact (AI) was created to help identify employment discrimination and is defined as a meaningful difference in the selection rates (e.g., hiring, admissions, promotion) between two groups of employees or applicants (e.g., men and women). Researchers studying fairness in organizations have treated AI almost entirely as if it ...
    • Spacecraft Parachute Fluid Mechanics Computation Based on Space--Time Isogeometric Analysis With T-splines 

      Avsar, Reha (2021-12-03)
      This thesis is on fluid and structural mechanics computation of spacecraft parachutes based on isogeometric discretization with T-splines. Contrary to the non-uniform rational B-splines (NURBS), T-spline representation does not require a regular control grid, allowing a set of control points to end without traversing the whole domain. We generate a ...
    • Sources and Characterization of Ozone and Submicron Aerosol in San Antonio, Texas 

      Guo, Fangzhou (2021-12-02)
      The work presented here describes the observations of 1) the criteria air pollutant ozone (O3) and its precursors- nitrogen oxides (NOX) and volatile organic compounds (VOCs) and 2) non-refractory submicron aerosol (NR-PM1) at two sites in the city of San Antonio, Texas. Chemical modeling and source apportionment techniques are used to characterize ...
    • Development of highly multiplex nucleic acid-based diagnostic technologies 

      Xie, Guanyi (2021-12-02)
      The design of highly multiplex nucleic acid primers and probes to enrich and detect many different DNA sequences is increasing in biomedical importance as new mutations and pathogens are identified. One major challenge in the design of highly multiplex PCR primer sets is the large number of potential primer dimer species that grows quadratically with ...
    • Origin of nitrogen and carbon in rocky bodies of the inner Solar System 

      Grewal, Damanveer Singh (2021-12-02)
      In this PhD thesis, I aim to answer one of the fundamental questions in modern science – What are the chemical pathways leading to the formation of Earth-like habitable planets? To this end, I have focused on the origin of two vital life-essential volatiles, nitrogen (N) and carbon (C), in the rocky bodies of the inner Solar System. I present a ...
    • Essays in Empirical Industrial Organization and Financial Economics 

      Amani Hamedani, Mahya (2021-12-02)
      This dissertation is composed of three essays in Empirical Industrial Organization and Financial Economics. The first essay, titled “Non-Compete Agreements in the Investment Advisory Industry,” studies how labor mobility constraints affect competition in the US investment advisory industry. In this industry, advisors play a critical role in the ...
    • Genetic suppressors reveal varying methods for improving peroxisome function in Arabidopsis peroxin mutants 

      Llinas, Roxanna J. (2021-12-02)
      Peroxisomes are eukaryotic organelles that support several metabolic pathways critical to survival and development. These pathways include diverse oxidative reactions with harmful reactive byproducts that are neutralized with enzymes accumulated in peroxisomes. New peroxisomes can be generated via de novo formation from the endoplasmic reticulum or ...
    • Feature Learning and Bayesian Functional Regression for High-Dimensional Complex Data 

      Zohner, Ye Emma M (2021-12-02)
      In recent years, technological innovations have facilitated the collection of complex, high-dimensional data that pose substantial modeling challenges. Most of the time, these complex objects are strongly characterized by internal structure that makes sparse representations possible. If we can learn a sparse set of features that accurately captures ...
    • Evaluate Namespace as a Labeling System for Malware Detection 

      Ding, Chenkai (2021-12-02)
      Nowadays, kernel tracing tools are built on limited Linux features. In this thesis, we explore a new method to help improving kernel tracing. We modified Memorizer, a novel kernel tracing tool that offers a comprehensive coverage of kernel accesses, and combined it with the Linux Namespace system. As an original compartment feature in Linux, introducing ...
    • "I am Not an Immigrant But I Happen to Live Here": Negotiating Ethnicity Among First-Generation Post-1965 Japanese Migrants in US Immigrant Gateway City 

      Zhang, Xiaorui (2021-12-02)
      The history of Japanese immigration to the United States is a well-established inquiry in Asian American scholarship. However, we know less about the incorporation experiences of contemporary Japanese who migrated to the United States after 1965. Drawing on in-depth interviews with 25 first-generation post-1965 Japanese migrants in Houston, Texas, ...
    • Space Radiation Interactions in Earth's Atmosphere, Low Earth Orbit, and Deep Space 

      Chanthavane, Spence Lim (2021-12-01)
      This thesis explores various radiation transport toolkits to more accurately calculate pilot radiation exposure. Radiation exposure and its harmful effects on the human body are explored with the use of three simulation codes: DYASTIMA-R, MULASSIS, and HZETRN. Absorbed and equivalent dose values for seventeen different altitudes between 31,000 ft to ...
    • Manifold Approximating Graph Interpolation of Cardiac Local Activation Time 

      Hellar, Jennifer (2021-12-01)
      Local activation time (LAT) mapping of cardiac chambers is vital for targeted treatment of cardiac arrhythmias in catheter ablation procedures. Current methods require many LAT observations for an accurate interpolation of the LAT signal extracted from intracardiac electrograms (EGMs). Additionally, conventional performance metrics do not accurately ...
    • Caenorhabditis elegans as a tool for high-throughput screening and gene network analysis 

      Anderson, Quinton Levi (2021-12-01)
      Often, we think of mitochondria as simply as the powerhouse of the cell, but we have come to understand that they are crucial to multiple facets of cellular health. Mitochondria are involved in the production of ROS (reactive oxygen species), fatty acid metabolism, and calcium storage. Mitochondria are also extremely dynamic organelles that undergo ...
    • Microfluidic tools for studying epithelial tissues under shear flow with vasculature and microstructures 

      Hewes, Sarah (2021-12-01)
      Cells are subject to a wide range of mechanical stimulation and structural elements that affect their function. There is a need for platforms and methods that better model the physiology of complex tissues, such as the small intestine. In this thesis, I present tools for studying cells under laminar shear flow as well as micropatterning techniques ...