Now showing items 1-20 of 13411

    • Gold Nanorod Size Prediction from Spectra Assisted by Machine Learning 

      Shiratori, Katsuya (2022-06-07)
      Electron microscopy is often required to correlate the size and shape of plasmonic nanoparticles with their optical properties. Eliminating the need for electron microscopy is one crucial step toward in situ sensing applications, especially for complicated sample conditions such as during irreversible chemical reactions or when particles are embedded ...
    • Gold Nanorod Size Prediction from Spectra Assisted by Machine Learning 

      Shiratori, Katsuya (2022-06-07)
      Electron microscopy is often required to correlate the size and shape of plasmonic nanoparticles with their optical properties. Eliminating the need for electron microscopy is one crucial step toward in situ sensing applications, especially for complicated sample conditions such as during irreversible chemical reactions or when particles are embedded ...
    • A comprehensive overview of triterpene biosynthesis in tomato through genomics and metabolomics 

      Frousnoon, Thasneem Banu (2022-04-25)
      Oxidosqualene cyclases (OSCs) are enzymes that cyclize the substrate 2,3-oxidosqualene into triterpenes, a major group of natural products. This thesis presents the characterization of OSCs in tomato by heterologous expression and the triterpene metabolic profile in each plant part. Detailed OSC product profiles, coupled with phylogenetic analysis, ...
    • Phase transitions in the rheology of biopolymer networks 

      Shivers, Jordan L. (2022-03-14)
      Most biological materials are stabilized internally by disordered networks of long, thin protein assemblies known as biopolymers. These networks occupy a negligible fraction of the space inside cells and tissues, yet are largely responsible for their extraordinary mechanical properties and exceptional resilience against unpredictable physiological ...
    • Phase transitions in the rheology of biopolymer networks 

      Shivers, Jordan L. (2022-03-14)
      Most biological materials are stabilized internally by disordered networks of long, thin protein assemblies known as biopolymers. These networks occupy a negligible fraction of the space inside cells and tissues, yet are largely responsible for their extraordinary mechanical properties and exceptional resilience against unpredictable physiological ...
    • Modeling Disjunctive Constraints via Junction Trees 

      Lyu, Bochuan (2021-12-22)
      In this thesis, we study the independent-branching (IB) framework of disjunctive constraints and identify a class of pairwise IB-representable disjunctive constraints: disjunctive constraints with junction trees. For this class of constraints, the existence of junction trees can be recognized in polynomial time. We also present a polynomial-time ...
    • Network Modeling Approaches Leveraging Higher Order Dependence for Complex Biomedical Data 

      Desai, Neel Mehul (2021-12-21)
      In this work I propose three network modeling approaches that estimate and leverage dependence in novel ways across and within networks to enhance the inference of complex modern biomedical data. Specifically, our methods are motivated by the personalized drug discovery problem in precision medicine and by the identification of factors explaining ...
    • Affective Haptic Vest for Facilitating Interpersonal Communication 

      Baldwin, Jacar (2021-12-21)
      Touch plays an important role in deepening human connection. The emerging field of Affective Haptics seeks to analyze and design systems capable of processing human emotions through touch. There is an increasing focus on using the sense of touch to assist in communicating information: in entertainment, treatment procedures in social and developmental ...
    • Development of New Methods for Easy-to-apply, Multiplexed and Ultrasensitive Nucleic-Acid based Diagnostic Technologies 

      Zhang, Carol (2021-12-09)
      The Polymerase chain reaction (PCR) has been one of the most widely used and easily accessible methods in bio-laboratories. It could be used in a fluorescence detection device together with intercalating dyes or fluorophore-labeled probes to achieve real-time quantitation of nucleic acid targets, or it could be involved in the workflow of high- ...
    • Free Labor, Free Trade, and Free Immigration: The Vision of Pacific Community after the Civil War 

      Ha, Arang (2021-12-03)
      My dissertation explores the rise and fall of the vision of “Pacific community” in the decades following the Civil War. It approaches this narrative through the ideas and activities of the “antislavery internationalists” who envisioned connecting the American West and East Asia into a single economic zone. They believed that the transpacific networks ...
    • Targeting Mitochondria Metabolisms for Novel AML Therapy Development 

      Pei, Jingqi (2021-12-03)
      Mitochondrial dysfunction contributes to a wide variety of pathologies, including neurodegenerative diseases, cancer, metabolic diseases, and aging. As a consequence, oncogenesis and tumor progression heavily depends on the mitochondrial metabolism. I investigated the potential of using mitochondrial targeting drugs to selectively remove leukemia, a ...
    • Dynamics of a Synthetic Microbial Community in a Structured Droplet Environment 

      Ganiga Prabhakar, Ramya (2021-12-03)
      In nature, microbes live in multispecies communities where they compete for nutrients within a localized and sometimes structured environment. Outcomes of such microbial interactions are dynamic and can vary in response to environmental cues. To study community dynamics in laboratory conditions, the choice of culturing environments is therefore ...
    • Life Course Contexts and Racial Birth Outcome Disparities 

      Freeman Cenegy, Laura (2021-12-03)
      ABSTRACT Life Course Contexts and Racial Birth Outcome Disparities by Laura Freeman Cenegy This dissertation investigates one of the most heavily researched, yet poorly understood, manifestations of racial health inequality in the U.S., the black-white gap in infant health at birth. I examine the ways in which life course family and contextual ...
    • A Synthetic Intercellular Toggle Switch and its Implications on Pattern Formation 

      de Freitas Magalhaes, Barbara (2021-12-03)
      A genetic toggle switch is a circuit that possesses two stable mutually exclusive states of gene expression caused by cross-repression. It is widely found in natural processes, such as in development, given that cross-repression is important for refining pattern boundaries. Synthetically, many circuits that are applied to biotechnology are also based ...
    • Contrast Agent Development for Molecular Imaging of Cancer 

      Pollard, Alyssa Camille (2021-12-03)
      This dissertation focuses on the design, synthesis, and application of contrast agents for molecular imaging. Specifically, these agents have been designed to probe specific tumor biomarkers such as pH or cancer metabolism to provide information related to tumor biology. Two sets of positron emission tomography/magnetic resonance imaging (PET/MRI) ...
    • Effect of Versatile Structural Design on Properties and Applications of Two-Dimensional Conjugated Microporous Polymer Thin Films 

      Miller, Kristen A. (2021-12-03)
      Microporous two-dimensional (2D) polymers have great potential in many applications given their covalent bonding in two dimensions, extended conjugated structures, high surface areas and functional design. However, their widespread implementation in practical application spaces has so far been limited by the lack of facile and scalable processing ...
    • Understanding How Divergence in Diet Breadth and the Degree of Environmental Variability Contribute to Individual Differences in Decision-Making and Learning 

      Burns, Madeline (2021-12-03)
      The broad focus of my dissertation has been investigating the various selection pressures contributing to the variation we observe in animal cognition, and how that variation evolves. Thus far, my work has primarily investigated how divergence in habitat breadth contributes to variation in decision-making and learning; more specifically, how environmental ...
    • Measuring Subjective Usability by Watching Others Use the Product 

      Shanklin, Roslyn Ayanna (2021-12-03)
      The COVID-19 pandemic instituted a new norm for usability practitioners and researchers by limiting their ability to safely conduct in-person, contact-intensive usability testing protocols. This study explored one promising remote usability assessment method, Watching Others Using Video, wherein users watch videos of others using a product and then ...
    • Tracing oxygen cycling in the ocean by dissolved oxygen multi-isotopologues 

      Li, Boda (2021-12-03)
      Understanding the distribution and cycling of O2 is one of the core scientific questions in oceanography. The distribution of dissolved oxygen is influenced by physical, biochemical, and abiotic chemical processes. However, determining the relative importance of each mechanism in different environments remains difficult. This thesis utilizes the ...
    • One-Dimensional Gravity Sedimentation of Proppant 

      Li, Yali (2021-12-03)
      To better understand the two-dimensional proppant transport problem in vertical fracture, we use the Method of Characteristics (MOC) to simulate one-dimensional sedimentation of suspensions by gravity. Literature survey and background about proppant transport are introduced first. The theory of sedimentation and MOC is then illustrated. The empirical ...