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dc.contributor.authorHecht, Inbal
Natan, Sari
Zaritsky, Assaf
Levine, Herbert
Tsarfaty, Ilan
Ben-Jacob, Eshel
dc.date.accessioned 2015-11-09T18:52:17Z
dc.date.available 2015-11-09T18:52:17Z
dc.date.issued 2015
dc.identifier.citation Hecht, Inbal, Natan, Sari, Zaritsky, Assaf, et al.. "The motility-proliferation-metabolism interplay during metastatic invasion." Scientific Reports, 5, (2015) Nature Publishing Group: http://dx.doi.org/10.1038/srep13538.
dc.identifier.urihttps://hdl.handle.net/1911/82036
dc.description.abstract Metastasis is the major cause for cancer patients’ death, and despite all the recent advances in cancer research it is still mostly incurable. Understanding the mechanisms that are involved in the migration of the cells in a complex environment is a key step towards successful anti-metastatic treatment. Using experimental data-based modeling, we focus on the fundamentals of metastatic invasion: motility, invasion, proliferation and metabolism, and study how they may be combined to maximize the cancer’s ability to metastasize. The modeled cells’ performance is measured by the number of cells that succeed in migration in a maze, which mimics the extracellular environment. We show that co-existence of different cell clones in the tumor, as often found in experiments, optimizes the invasive ability in a frequently-changing environment. We study the role of metabolism and stimulation by growth factors, and show that metabolism plays a crucial role in the metastatic process and should therefore be targeted for successful treatment.
dc.language.iso eng
dc.publisher Nature Publishing Group
dc.rights This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the articleメs Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.title The motility-proliferation-metabolism interplay during metastatic invasion
dc.type Journal article
dc.contributor.funder 7th European Community Framework Programme
dc.contributor.funder Breast Cancer Research Foundation
dc.contributor.funder US — Israel Binational Science Foundation
dc.contributor.funder Tauber Family Foundation
dc.contributor.funder National Science Foundation, Center for Theoretical Biological Physics
dc.contributor.funder Cancer Prevention and Research Inst
dc.citation.journalTitle Scientific Reports
dc.contributor.org Center for Theoretical Biological Physics
dc.citation.volumeNumber 5
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1038/srep13538
dc.identifier.pmid 26337223
dc.identifier.grantID Marie Curie International Reintegration Grant (7th European Community Framework Programme)
dc.identifier.grantID PHY-1308264 (National Science Foundation, Center for Theoretical Biological Physics)
dc.type.publication publisher version


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This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the articleメs Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material.
Except where otherwise noted, this item's license is described as This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the articleメs Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material.