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dc.contributor.authorCorr, Stuart J.
Shamsudeen, Sabeel
Vergara, Leoncio A.
Ho, Jason Chak-Shing
Ware, Matthew J.
Keshishian, Vazrik
Yokoi, Kenji
Savage, David J.
Meraz, Ismail M.
Kaluarachchi, Warna
Cisneros, Brandon T.
Raoof, Mustafa
Nguyen, Duy Trac
Zhang, Yingchun
Wilson, Lon J.
Summers, Huw
Rees, Paul
Curley, Steven A.
Serda, Rita E.
dc.date.accessioned 2015-10-30T15:40:41Z
dc.date.available 2015-10-30T15:40:41Z
dc.date.issued 2015
dc.identifier.citation Corr, Stuart J., Shamsudeen, Sabeel, Vergara, Leoncio A., et al.. "A New Imaging Platform for Visualizing Biological Effects of Non-Invasive Radiofrequency Electric-Field Cancer Hyperthermia." PLoS ONE, 10, no. 8 (2015) e0136382. http://dx.doi.org/10.1371/journal.pone.0136382.
dc.identifier.urihttps://hdl.handle.net/1911/82002
dc.description.abstract Herein, we present a novel imaging platform to study the biological effects of non-invasive radiofrequency (RF) electric field cancer hyperthermia. This system allows for real-time in vivointravital microscopy (IVM) imaging of radiofrequency-induced biological alterations such as changes in vessel structure and drug perfusion. Our results indicate that the IVM system is able to handle exposure to high-power electric-fields without inducing significant hardware damage or imaging artifacts. Furthermore, short durations of low-power (< 200 W) radiofrequency exposure increased transport and perfusion of fluorescent tracers into the tumors at temperatures below 41°C. Vessel deformations and blood coagulation were seen for tumor temperatures around 44°C. These results highlight the use of our integrated IVM-RF imaging platform as a powerful new tool to visualize the dynamics and interplay between radiofrequency energy and biological tissues, organs, and tumors.
dc.language.iso eng
dc.rights This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.title A New Imaging Platform for Visualizing Biological Effects of Non-Invasive Radiofrequency Electric-Field Cancer Hyperthermia
dc.type Journal article
dc.contributor.funder National Institutes of Health, Physical Science in Oncology Program
dc.contributor.funder National Institutes of Health M.D. Anderson Cancer Center Support Grants
dc.contributor.funder Welch Foundation
dc.contributor.funder Kanzius 617 Research Foundation
dc.contributor.funder National Institutes of Health, National Center for Advancing Translational Sciences
dc.citation.journalTitle PLoS ONE
dc.citation.volumeNumber 10
dc.citation.issueNumber 8
dc.contributor.publisher Public Library of Science
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0136382
dc.identifier.grantID U54CA143837 (National Institutes of Health, Physical Science in Oncology Program)
dc.identifier.grantID CA016672 (National Institutes of Health M.D. Anderson Cancer Center Support Grants)
dc.identifier.grantID C-0627 (Welch Foundation)
dc.identifier.grantID TL1TR000369 (National Institutes of Health, National Center for Advancing Translational Sciences)
dc.identifier.grantID UL1TR000371 (National Institutes of Health, National Center for Advancing Translational Sciences)
dc.type.publication publisher version
dc.citation.firstpage e0136382


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This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Except where otherwise noted, this item's license is described as This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.