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dc.contributor.authorNicolaou, K.C.
Heretsch, Philipp
ElMarrouni, Abdelatif
Hale, Christopher R.H.
Pulukuri, Kiran K.
Kudva, Avinash K.
Narayan, Vivek
Prabhu, K. Sandeep
dc.date.accessioned 2015-10-29T18:23:24Z
dc.date.available 2015-10-29T18:23:24Z
dc.date.issued 2014
dc.identifier.urihttp://hdl.handle.net/1911/81982
dc.description.abstract A catalytic asymmetric total synthesis of the potent and selective antileukemic Δ12-prostaglandin J3 (Δ12-PGJ3) is described. The convergent synthesis proceeded through intermediates 2 and 3, constructed enantioselectively from readily available starting materials and coupled through an aldol reaction followed by dehydration to afford stereoselectively the cyclopentenone alkylidene structural motif of the molecule.
dc.language.iso eng
dc.rights This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Wiley.
dc.title Total Synthesis of Δ12-Prostaglandin J3, a Highly Potent and Selective Antileukemic Agent
dc.type Journal article
dc.contributor.funder Cancer Prevention Research Institute of Texas
dc.contributor.funder Welch Foundation
dc.contributor.funder Rice University
dc.contributor.funder National Institutes of Health
dc.citation.journalTitle Angewandte Chemie
dc.contributor.org BioScience Research Collaborative
dc.subject.keywordasymmetric catalysis
CヨH activation
leukemia
natural products
total synthesis
dc.citation.volumeNumber 126
dc.citation.issueNumber 39
dc.contributor.publisher Wiley
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1002/ange.201404917
dc.identifier.pmcid PMC4169176
dc.identifier.pmid 25098181
dc.identifier.grantID R01 CA175576 (National Institutes of Health)
dc.type.publication post-print
dc.citation.firstpage 10611
dc.citation.lastpage 10615
dc.identifier.citation Nicolaou, K.C., Heretsch, Philipp, ElMarrouni, Abdelatif, et al., . "Total Synthesis of Δ12-Prostaglandin J3, a Highly Potent and Selective Antileukemic Agent." Angewandte Chemie, 126, no. 39 (2014) 10611-10615. http://dx.doi.org/10.1002/ange.201404917.


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