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dc.contributor.authorNicolaou, K.C.
Shi, Lei
Lu, Min
Pattanayak, Manas R.
Shah, Akshay A.
Ioannidou, Heraklidia A.
Lamani, Manjunath
dc.date.accessioned 2015-10-29T18:23:24Z
dc.date.available 2015-10-29T18:23:24Z
dc.date.issued 2014
dc.identifier.citation Nicolaou, K.C., Shi, Lei, Lu, Min, et al.. "Total Synthesis of Myceliothermophins C, D and E." Angewandte Chemie International Edition, 53, no. 41 (2014) Wiley: 10970-10974. http://dx.doi.org/10.1002/anie.201406815.
dc.identifier.urihttps://hdl.handle.net/1911/81981
dc.description.abstract The total synthesis of cytotoxic polyketides myceliothermophins E (1), C (2) and D (3) through a cascade-based cyclization to form the trans-fused decalin system is described. The convergent synthesis delivered all three natural products through late-stage divergence and facilitated unambiguous C21 structural assignments for 2 and 3 through X-ray crystallographic analysis which revealed an interesting dimeric structure between its enantiomeric forms.
dc.language.iso eng
dc.publisher Wiley
dc.rights This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Wiley.
dc.title Total Synthesis of Myceliothermophins C, D and E
dc.type Journal article
dc.contributor.funder Cancer Prevention & Research Institute of Texas
dc.contributor.funder National Institutes of Health
dc.contributor.funder National Science Foundation
dc.contributor.funder Rice University
dc.contributor.funder Bristol-Myers Squibb
dc.contributor.funder European Commission
dc.citation.journalTitle Angewandte Chemie International Edition
dc.contributor.org BioScience Research Collaborative
dc.subject.keywordcascade reaction
decalin
natural products
polyketides
total synthesis
dc.citation.volumeNumber 53
dc.citation.issueNumber 41
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1002/anie.201406815
dc.identifier.pmcid PMC4257465
dc.identifier.pmid 25163463
dc.identifier.grantID AI0055475 (National Institutes of Health)
dc.type.publication post-print
dc.citation.firstpage 10970
dc.citation.lastpage 10974


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