Total Synthesis of Myceliothermophins C, D and E
Author
Date
2014Abstract
The total synthesis of cytotoxic polyketides myceliothermophins E (1), C (2) and D (3) through a cascade-based cyclization to form the trans-fused decalin system is described. The convergent synthesis delivered all three natural products through late-stage divergence and facilitated unambiguous C21 structural assignments for 2 and 3 through X-ray crystallographic analysis which revealed an interesting dimeric structure between its enantiomeric forms.
Citation
Published Version
Keyword
cascade reaction; decalin; natural products; polyketides; total synthesis
Type
Journal article
Publisher
Citable link to this page
https://hdl.handle.net/1911/81981Rights
This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Wiley.Metadata
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