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dc.contributor.authorSantoro, Marco
Tatara, Alexander M.
Mikos, Antonios G.
dc.date.accessioned 2015-10-28T19:04:03Z
dc.date.available 2015-10-28T19:04:03Z
dc.date.issued 2014
dc.identifier.citation Santoro, Marco, Tatara, Alexander M. and Mikos, Antonios G.. "Gelatin carriers for drug and cell delivery in tissue engineering." Journal of Controlled Release, 190, (2014) Elsevier: 210-218. http://dx.doi.org/10.1016/j.jconrel.2014.04.014.
dc.identifier.urihttps://hdl.handle.net/1911/81939
dc.description.abstract The ability of gelatin to form complexes with different drugs has been investigated for controlled release applications. Gelatin parameters, such as crosslinking density and isoelectric point, have been tuned in order to optimize gelatin degradation and drug delivery kinetics. In recent years, focus has shifted away from the use of gelatin in isolation toward the modification of gelatin with functional groups and the fabrication of material composites with embedded gelatin carriers. In this review, we highlight some of the latest work being performed in these areas and comment on trends in the field. Specifically, we discuss gelatin modifications for immune system evasion, drug stabilization, and targeted delivery, as well as gelatin composite systems based on ceramics, naturally-occurring polymers, and synthetic polymers.
dc.language.iso eng
dc.publisher Elsevier
dc.rights This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.
dc.title Gelatin carriers for drug and cell delivery in tissue engineering
dc.type Journal article
dc.contributor.funder Armed Forces Institute of Regenerative Medicine
dc.contributor.funder National Institutes of Health
dc.citation.journalTitle Journal of Controlled Release
dc.subject.keywordgelatin
drug delivery
cell delivery
controlled release
composite material
dc.citation.volumeNumber 190
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1016/j.jconrel.2014.04.014
dc.identifier.pmcid PMC4142078
dc.identifier.pmid 24746627
dc.identifier.grantID W81XWH-14-2-0004 (Armed Forces Institute of Regenerative Medicine)
dc.identifier.grantID R01 AR048756 (National Institutes of Health)
dc.identifier.grantID R01 AR057083 (National Institutes of Health)
dc.identifier.grantID T32 GM007330 (National Institutes of Health)
dc.type.publication post-print
dc.citation.firstpage 210
dc.citation.lastpage 218


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