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dc.contributor.authorMcRae, Michael P.
Simmons, Glennon W.
Wong, Jorge
Shadfan, Basil
Gopalkrishnan, Sanjiv
Christodoulides, Nicolaos
McDevitt, John T.
dc.date.accessioned 2015-09-24T18:13:01Z
dc.date.available 2015-09-24T18:13:01Z
dc.date.issued 2015
dc.identifier.citation McRae, Michael P., Simmons, Glennon W., Wong, Jorge, et al.. "Programmable bio-nano-chip system: a flexible point-of-care platform for bioscience and clinical measurements." Lab on a Chip, (2015) Royal Society of Chemistry: http://dx.doi.org/10.1039/C5LC00636H.
dc.identifier.urihttps://hdl.handle.net/1911/81712
dc.description.abstract The development of integrated instrumentation for universal bioassay systems serves as a key goal for the lab-on-a-chip community. The programmable bio-nano-chip (p-BNC) system is a versatile multiplexed and multiclass chemical- and bio-sensing system for bioscience and clinical measurements. The system is comprised of two main components, a disposable cartridge and a portable analyzer. The customizable single-use plastic cartridges, which now can be manufactured in high volumes using injection molding, are designed for analytical performance, ease of use, reproducibility, and low cost. These labcard devices implement high surface area nano-structured biomarker capture elements that enable high performance signaling and are index-matched to real-world biological specimens. This detection modality, along with the convenience of on-chip fluid storage in blisters and self-contained waste, represents a standard process to digitize biological signatures at the point-of-care. A companion portable analyzer prototype has been developed to integrate fluid motivation, optical detection, and automated data analysis, and it serves as the human interface for complete assay automation. In this report, we provide a systems-level perspective of the p-BNC universal biosensing platform with an emphasis on flow control, device integration, and automation. To demonstrate the flexibility of the p-BNC, we distinguish diseased and non-case patients across three significant disease applications: prostate cancer, ovarian cancer, and acute myocardial infarction. Progress towards developing a rapid 7 minute myoglobin assay is presented using the fully automated p-BNC system.
dc.language.iso eng
dc.publisher Royal Society of Chemistry
dc.rights This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the Royal Society of Chemistry.
dc.title Programmable bio-nano-chip system: a flexible point-of-care platform for bioscience and clinical measurements
dc.type Journal article
dc.contributor.funder National Institutes of Health, National Institute of Dental and Craniofacial Research
dc.citation.journalTitle Lab on a Chip
dc.type.dcmi Text
dc.identifier.doihttp://dx.doi.org/10.1039/C5LC00636H
dc.identifier.pmid 26308851
dc.identifier.grantID 3 U01 DE017793-02S1 (National Institutes of Health, National Institute of Dental and Craniofacial Research)
dc.identifier.grantID 5 U01 DE017793-2 (National Institutes of Health, National Institute of Dental and Craniofacial Research)
dc.type.publication post-print


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