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    Quantitative evaluation of in vivo vital-dye fluorescence endoscopic imaging for the detection of Barrett’s-associated neoplasia

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    Author
    Thekkek, Nadhi
    Lee, Michelle H.
    Polydorides, Alexandros D.
    Rosen, Daniel G.
    Anandasabapathy, Sharmila
    Richards-Kortum, Rebecca
    Date
    2015
    Citation
    Thekkek, Nadhi, Lee, Michelle H., Polydorides, Alexandros D., et al.. "Quantitative evaluation of in vivo vital-dye fluorescence endoscopic imaging for the detection of Barrett’s-associated neoplasia." Journal of Biomedical Optics, 20, no. 5 (2015) 56002. http://dx.doi.org/10.1117/1.JBO.20.5.056002.
    Published Version
    http://dx.doi.org/10.1117/1.JBO.20.5.056002
    Abstract
    Current imaging tools are associated with inconsistent sensitivity and specificity for detection of Barrett’s-associated neoplasia. Optical imaging has shown promise in improving the classification of neoplasia in vivo. The goal of this pilot study was to evaluate whether in vivo vital dye fluorescence imaging (VFI) has the potential to improve the accuracy of early-detection of Barrett’s-associated neoplasia. In vivo endoscopic VFI images were collected from 65 sites in 14 patients with confirmed Barrett’s esophagus (BE), dysplasia, or esophageal adenocarcinoma using a modular video endoscope and a high-resolution microendoscope (HRME). Qualitative image features were compared to histology; VFI and HRME images show changes in glandular structure associated with neoplastic progression. Quantitative image features in VFI images were identified for objective image classification of metaplasia and neoplasia, and a diagnostic algorithm was developed using leave-one-out cross validation. Three image features extracted from VFI images were used to classify tissue as neoplastic or not with a sensitivity of 87.8% and a specificity of 77.6% (AUC=0.878). A multimodal approach incorporating VFI and HRME imaging can delineate epithelial changes present in Barrett’s-associated neoplasia. Quantitative analysis of VFI images may provide a means for objective interpretation of BE during surveillance.
    Keyword
    fluorescence imaging; Barrett's esophagus; endoscopy; esophageal adenocarcinoma; neoplasia; More... contrast agents Less...
    Type
    Journal article
    Citable link to this page
    http://hdl.handle.net/1911/80841
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    • Bioengineering Publications [397]
    • Faculty Publications [2827]

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    Managed by the Digital Scholarship Services at Fondren Library, Rice University
    Physical Address: 6100 Main Street, Houston, Texas 77005
    Mailing Address: MS-44, P.O.BOX 1892, Houston, Texas 77251-1892