Native NAD-dependent GAPDH replaced with NADP-dependent GAPDH plus NADK
AuthorSan, Ka-Yiu; Bennett, George N.; Wang, Yipeng
This invention is metabolically engineer bacterial strains that provide increased intracellular NADPH availability for the purpose of increasing the yield and productivity of NADPH-dependent compounds. In the invention, native NAD-dependent GAPDH is replaced with NADP-dependent GAPDH plus overexpressed NADK. Uses for the bacteria are also provided.
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- Rice Patents