Nerolidol- terpene- and terpene deriviative synthesis
AuthorMcNeil, Caroline Virginia; Morlacchi, Pietro; Baevich, Alyssa; Matsuda, Seiichi P. T.
According to one embodiment, the description relates to a method of nerolidol production. The method includes culturing a yeast strain lacking functional squalene synthase and overproducing HMG CoA reductase in synthetic medium lacking uracil and producing nerolidol. The pH of the medium may be adjusted to an acidic level to further increase nerolidol production. Other chemicals may also be produced by this method. The nerolidol or other chemicals may be removed from the yeast or medium or both. The medium may additionally contain a polyaromatic resin, which may adsorb nerolidol or other chemicals.
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