Pantothenate kinase overexpression and pantothenic acid supplementation in actinomycetes
AuthorLee, Hei Chan; Sohng, Jae Kyung; San, Ka-Yiu
The invention relates to the synthesis of polyketides in Actinomycetes by overexpression of pantothenate kinase and supplementation with pantothenic acid. This results in increasing in vivo CoA production and thereby drives increased production of secondary metabolites, such as polyketides.
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- Rice Patents